In HCC, the major pathways involved in the oncogenic process are WNT/b-catenin, Hedgehog, hepatocyte growth factor/c-MET, vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK)/ERK (or Ras-Raf-MEK-ERK) and PI3K/AKT/mTOR [3,4]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.