Cholestatic liver diseases result from a repeated exposure to unconjugated primary biliary acids, which may activate mTOR through the IκB kinase β (IKKβ)/Tuberous sclerosis 1 (TSC1)/mTOR pathway as demonstrated in some precancerous conditions such as Barrett’s esophagus [48]. The gene discussed is MTOR; the disease is esophageal adenocarcinoma.