SREBF1 and alcoholic liver diseases: This metabolic reprogramming in alcoholic liver disease requires the activation of mTORC1 by downregulating DEP domain-containing mTOR-interacting protein (DEPTOR, an upstream inhibitor of the complex) [28], and by inhibiting AMPK, which results in the upregulation of lipogenic gene sterol regulatory element binding protein-1 (SREBP1), and in the reduction of circulating adiponectin and peroxisome proliferator activated receptor-alpha (PPAR-alpha) [29].