SIRT1 and Alzheimer disease: Moreover, resveratrol upregulates the Sirt1 pathway, thus preventing Aβ-induced microglial death and contributing to improve cognitive function [166] and induces the SIRT-1 and TRX signaling pathways with reduction of Aβ-stimulated NF-κB signaling, that contributes to its strong neuroprotection in AD [167,168,169,170].