In particular, many recent data suggest the key role played by phenolic components of EVOO in counteracting protein misfolding and proteotoxicity, with a particular emphasis on the mechanisms leading to the onset and progression of AD and PD, including APP processing, Aβ peptide and tau amyloid aggregation, autophagy impairment, disruption of redox homeostasis, α-synuclein neurotoxicity, and neuroinflammation [48,72]. The gene discussed is MAPT; the disease is Alzheimer disease.