TTR and renal fibrosis: Both CTS-induced Na/K-ATPase signaling and ROS generation are involved in the development of cardiac and renal fibrosis since CTS-stimulated signaling and fibrosis could be attenuated by ROS scavenging, c-Src inhibition, and competitive inhibition of CTS binding to Na/K-ATPase by spironolactone and canrenone [55,90,95,96].