Figure 4e reveals the attenuation of integrin β1 and αV in human lung cancer H460 cells treated with 15 μM of colicin N for 12 h. Interestingly, significant reduction of integrin β1 was found even with lower concentrations (5–10 μM) of colicin N. In connection, alteration of Akt and Erk, which are downstream survival molecules of integrins was demonstrated in Figure 4f. This evidence concerns the gene AKT1 and lung cancer.