Overall, the intensity profiles of the lamins and emerin were brilliant (Figure 4B,B’), and the frequency of their mean value distribution were significantly different, being lamin A/C and emerin less expressed in MG63 than OBs, while lamin B1 mean fluorescence intensity was higher in the osteosarcoma cell line, in comparison to normal OBs (Figure 4C). The gene discussed is LMNB1; the disease is osteosarcoma.