Conversely, defects in B-type lamins are rare events and reported in some genetic diseases as the adult-onset autosomal dominant leukodystrophy (ADLD) associated to LMNB1 duplication or LMNB1 promoter mutation [17,18], and the partial lypodystrophy associated to LMNB2 heterozygous mutations [19,20,21]. The gene discussed is LMNB1; the disease is adult-onset autosomal dominant demyelinating leukodystrophy.