LMNB1 and Adult-onset autosomal dominant leukodystrophy: Conversely, defects in B-type lamins are rare events and reported in some genetic diseases as the adult-onset autosomal dominant leukodystrophy (ADLD) associated to LMNB1 duplication or LMNB1 promoter mutation [17,18], and the partial lypodystrophy associated to LMNB2 heterozygous mutations [19,20,21].