Likewise, the nuclear localization of the Yes-Associated Protein (YAP), known to be related to A-type lamin expression [36], was reduced in high aggressive cells in comparison to low aggressive osteosarcoma cells or normal osteoblasts, following the same reduction pattern of A-type lamin (Figure 11C), as confirmed by fluorescence quantification analysis (Figure 11D). The gene discussed is YAP1; the disease is osteosarcoma.