Further, the functional effects of A-type lamin alterations was investigated by the analysis of immunoexpression and subcellular distribution of (MKL1), protein Retinoblastoma (pRb) and Yes-Associated Protein (YAP), known as functional sensors of A-type lamin perturbations, in osteoblasts and osteosarcoma cell lines. This evidence concerns the gene YAP1 and osteosarcoma.