While niclosamide has been reported to inhibit the NF-kB pathway and generate reactive oxygen species (ROS) to induce apoptosis in AML cells [15], niclosamide was found to share structural similarity with a small molecule inhibitor of cAMP Response Element Binding protein (CREB) and suppress the proliferation of AML cells by inhibiting CREB-dependent signaling pathways [19]. The gene discussed is CREB1; the disease is acute myeloid leukemia.