Among NK cell activating receptors involved in recognition and killing of MM, a prominent role is played by the activating receptor DNAX accessory molecule-1 (DNAM-1/CD226), able to bind to two adhesion molecules of nectin family of proteins, nectin2 (Nect-2/CD112) and poliovirus receptor (PVR/CD155) [20,21,22], on MM cells. This evidence concerns the gene NECTIN1 and Miyoshi myopathy.