Based on these observations, to gain further insight into the nature of the BMSC-secreted factors capable of inducing PVR expression on MM cells, we focused our attention on CXCR1/2 ligand CXCL8/IL-8, a chemokine produced by BMSCs and able to trigger NF-kB activation in MM cells [39]. This evidence concerns the gene CXCR1 and Miyoshi myopathy.