The possibility that these effects could be due to toxic and no specific effects of BMSC-CM on MM cells was excluded as these treatments did not affect cell viability over the time chosen for these experiments (as assessed by annexin V and propidium iodide staining) and the expression of MHC class I on SKO-007(J3) cells (Figure S2A,B). This evidence concerns the gene ANXA5 and Miyoshi myopathy.