Overall, a putative therapeutic approach based on miR-1272 reconstitution in association with ionizing radiation may improve PCa response to conventional radiotherapy, as we showed that miR-1272 can reduce the activity of EGFR/AKT/ERK1-2 pathways, known to be triggered as pro-survival signals upon irradiation. This evidence concerns the gene AKT1 and posterior cortical atrophy.