Based on the above referenced report and a known inhibitory function of β-OHB on NACHT-, LRR-, and pyrin (PYD)-domain-containing protein 3 (NLRP3) inflammasome pathway [24], we explored the potential therapeutic effect of β-OHB in murine AD and atherosclerosis model on ApoE−/− mice. This evidence concerns the gene APOE and Alzheimer disease.