PGF and neoplasm: An ECM-binding peptide derived from the placenta growth factor (PlGF-2), dubbed PlGF-2122–144 (sequence: RRRPKGRGKRRREKQRPTDCHL) bound to fibronectin, fibrinogen, osteopontin, vitronectin, and collagens I, II, III and IV with a KD in the low nM range for fibronectin I and collagen I. The peptide was coupled to the immune checkpoint inhibitors anti-CTLA4 and anti-PD-L1, which enhanced their tumor retention and increased their therapeutic effect [147].