Besides its presence in the ECM, CTGF is also expressed on endothelial cells, in cancer [134] and in early Alzheimer’s disease, thus DAG should be considered both an ECM and a vascular targeting ligand.DAG showed high accumulation in a patient-derived xenograft of glioblastoma, binding to activated astrocytes and extracellular matrix in the tumor. Here, CCN2 is linked to Alzheimer disease.