During obesity, MCP-1 binds to CC chemokine receptor 2 (CCR2) to initiate various monocyte-mediated proinflammatory signals and monocyte chemoattractant activities, facilitating monocytes migration to the subendothelium and combines with ox-LDL to form foam cells, forming a fatty streak and eventual atherosclerotic plaque (Figure 5) [85]. Here, CCL2 is linked to obesity due to melanocortin 4 receptor deficiency.