Calcitriol has also demonstrated apoptotic induction via the inhibition of the AKT (v-Akt murine thymoma viral oncogene homolog; protein kinase B)-mediated anti-apoptotic signaling pathway, by means of the upregulation of phosphatase and tensin homolog (PTEN) expression in the HGC-27 gastric cancer cell line [35]. This evidence concerns the gene PTEN and gastric cancer.