However, IL-33 expressed in the maxillary bone is associated with an exacerbated bone loss in a RANKL-dependent manner in the context of bacterial infection, such as in periodontitis, and ovariectomy-induced bone resorption is dependent on IL-33/ST2 signaling in the maxillae, but not in the femur or vertebrae, in a site-specific manner. Here, IL33 is linked to periodontitis.