ERBB2 and neoplasm: Comparison of gene expression in ECM3 vs. non-ECM3 tumors revealed significant enrichment for pathways we previously found associated with ECM3, such as EMT, cell and focal adhesion, TGF-beta pathway, tumor metastasis and hypoxia (Figure 1), confirming the biological characteristics of ECM3 tumors also among HER2-positive tumors.