For example, in NUP98-HOXD13-transformed AML, PBX3 was found to be necessary for the continued proliferation and survival of malignant cells [45], and suppression of PBX3 transcription through inhibition of the H3K79 methylase blocked the proliferation of NPM1-driven leukemia [11]. Here, PBX3 is linked to acute myeloid leukemia.