It is closely related to the hypercoagulable state observed even in early precancerous lesions, such as pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMNs), which are correlated with high levels of tissue factor (TF) expression [60], which in turn results in the activation of the coagulation cascade and the binding of TF to activated factor VII (FVIIa) and the formation of the TF–FVIIa complex [61,62]. The gene discussed is TF; the disease is pancreatic intraductal papillary-mucinous neoplasm.