This tumor cell–platelet aggregate formation is mediated by P-selectin, followed by L-selectin, which drives the recruitment of leucocytes, further resulting in shaping tumor cells containing thrombi that eventually reach a distant site of vascular arrest; tumor cells then activate endothelial cells, which in turn stimulate the expression of E-selectin that also mediates metastasis formation. This evidence concerns the gene SELP and neoplasm.