TGM2 and celiac disease: The major autoantigen in coeliac disease is TG2, a member of the TG family along with TG3, and untreated patients characteristically have TG2-targeting autoantibodies (e.g., TG2 and endomysial antibodies, EmA) in the circulation and within various tissues, including the small intestine; as deposits at the subepithelial basement membrane and around the blood vessels [15,16].