Animal studies have shown that prenatal overnutrition (e.g., high-fat diet) results in substantial changes in the development of the central appetitive structures, mainly the hypothalamic neural network [45,46], as well as epigenetic changes in adiponectin and leptin gene expression in offspring which are both adipocytokines and influence insulin sensitivity and the development of metabolic diseases [47]. The gene discussed is INS; the disease is Other metabolic disease.