Study of Tao has found that GAS5 could regulate cardiac fibroblast fibrosis by targeting miR‐21 to regulate PTEN/ MMP‐2 signaling pathway.29 In pancreatic cancer, GAS5 inhibits metastasis of pancreatic cancer cells by modulating the miR‐32‐5p/PTEN axis.30 Animal experiments in this study also showed that GAS5 and miR‐21 acted as antitumors by inducing expression of GAS5. Here, MMP2 is linked to familial pancreatic carcinoma.