SERPINA1 and primary biliary cholangitis: Together, these conditions are present in approximately 80% of individuals with CLD.[5] More rare causes include autoimmune liver diseases such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) and genetic conditions such as hereditary hemochromatosis, Wilson disease, and alpha-1 antitrypsin deficiency.