TNF and tuberculosis: Adding to the controversy, deficient chimeric mice rather suggested an important role of soluble LT-α in the control of Mtb infection [54], while the construction of LT-α knock-out mice able to produce normal levels of TNF-α pointed to a minor role of LT-α in the control of chronic TB compared to the major role of TNF-α in the control of acute Mtb infection [55].