For example, a main risk factor to developing such autoimmune conditions as: rheumatoid arthritis (RA), type 1 diabetes (T1D), and celiac disease (CD) are specific MHC class II alleles (RA/T1D: HLA-DR1, CD: HLA-DQ2.5/8) [3]. This evidence concerns the gene HLA-C and rheumatoid arthritis.