METTL3 and hereditary clear cell renal cell carcinoma: For example, it has been reported that METTL3 promotes ovarian carcinoma growth and epithelial to mesenchymal transition and promotes chemo‐ and radio‐resistance in pancreatic cancer cells14, 15; in contrast, METTL3 might act as a tumor suppressor in patients with renal cell carcinoma or endometrial cancer.16, 17 Despite being a m6A writer, very recent studies uncovered that METTL3 can regulate mRNA structure and subsequently promote oncogene translation independently on its m6A catalytic activity.18 Therefore, the mechanisms and role of METTL3 in cancer is probably very complex.