Similarly, as shown in Figure 6, compared with normal esophageal cell line, the expression levels of FGF14, KCNH6, LOC100506136, RGS7, SH3GL2, and THBS4 in esophageal cancer cells were significantly up-regulated in comparison with those in normal esophageal cells (all, P<0.05); however, the mRNA levels of CPLX2, DPEP1, EPHA5, SCGB1A1, and ST18 in esophageal cancer cells were significantly down-regulated (all, P<0.05), which is in accordance with the bioinformatics data above. This evidence concerns the gene THBS4 and esophageal cancer.