Eight of the 12 datasets were paired designs (e.g. monozygotic twins discordant for disease or pre‐/post‐interventions, Data S1), meaning that some of the 682 muscle samples were taken from healthy individuals at baseline or after a control diet, while other samples were taken after an exercise intervention, a high‐fat diet, sleep deprivation, insulin stimulation, or were from individuals with type 2 diabetes. The gene discussed is INS; the disease is type 2 diabetes mellitus.