A549, a human lung adenocarcinoma cell line, was incubated with A‐CpG ODN (D35), A‐CpG control ODN (D35A), B‐CpG ODN (K3), or B‐CpG control ODN (1612) (3 μM) and/or IFN‐γ (10 ng/mL) for 16 hours. The gene discussed is IFNG; the disease is lung adenocarcinoma.