It also induces immunosuppressive CD4+ and CD8+ T cells when bound to ligands expressed on dendritic cells.33, 34 IFN‐γ‐induced MDSCs play a major role in the survival and progression of cancer.35 In our study, we observed that ODNs containing poly‐G sequences may competitively inhibit the IFN‐γ receptor and abolish the action of IFN‐γ. This evidence concerns the gene CD8A and cancer.