Increased expression of HMGB2 in patients with hepatocellular carcinoma was significantly associated with shortened overall survival time.7, 20 Compared with adjacent normal breast tissues, HMGB2 is highly expressed in the nucleus of breast cancer cells.21 In our study, LINC00341 was combined with HMGB2 to form an inhibitory complex, stabilizing the location of HMGB2 cell formation. Here, SYNE3 is linked to hepatocellular carcinoma.