Genetic deficiencies of key mediators of the innate immune response, autosomal recessive IRAK4, and X-linked recessive IKBKG (encoding for NEMO) deficiencies, underlie pyogenic bacterial infection with impaired interleukin-6 (IL-6) production and C-reactive protein (CRP) production (Ku et al. 2007; Picard et al. 2003, 2011). The gene discussed is IKBKG; the disease is bacterial infectious disease.