KLF5 controls the stemness of embryonic stem cells.11 Nakaya and colleagues reported that KLF5 facilitated cell proliferation and survival of normal intestinal stem cells and was essential for the oncogenesis of intestinal tumours.13 These findings suggest that KLF5 acts as an indispensable stemness-related molecule in both normal and tumour tissues. This evidence concerns the gene KLF5 and intestinal neoplasm.