GSTM1 and colorectal carcinoma: A major advantage of FIT is that it provides a quantitative result, which allows shifting the cut-off value of the test and adapting it to the specific needs of the population to be screened.21–23 A recent meta-analysis demonstrated that FIT sensitivity for detection of CRC increased from 69% at cut-offs 10–20 μg Hb/g to 80% at cut-offs ≤10 μg Hb/g.24 Consistently, sensitivity for detection of advanced adenomas increased from 21 to 31% at these cut-off values.