EGFR and glioblastoma: Yet, due to the recent and ongoing development and clinical assessment of various EGFR and EGFRvIII-targeting strategies, such as peptide-based vaccines (rindopepimut), monoclonal antibody immunotoxin conjugates (ABT-414) or EGFRvIII-specific chimeric antigen receptor (CAR) T cells a deeper understanding of the molecular biology and clinical relevance of EGFR amplification and EGFRvIII in GBM is definitely required [24–27].