Examining the relationship of eIF4E protein expression with tamoxifen response in our TMA samples of 97 cases of ER+ breast cancer having clinical follow-up data, Pearson Chi-squared test showed eIF4E expression was significantly associated with Tamoxifen response (P = 0.016; Fig. 7d), with high eIF4E expression found in 57.1% patients with tamoxifen resistance; while low eIF4E expression was found in 67.3% tamoxifen sensitive patients (Fig. 7d). The gene discussed is EIF4E; the disease is breast cancer.