SH3BP5 and metabolic syndrome: It should also be noted that, although the contribution of Sab to JNK activation has been shown in limited types of cytotoxicity and disease models, numerous studies have demonstrated the pleiotropic functions and pivotal roles of JNK in the pathogenesis of diseases linked with TFAs, such as inflammatory diseases, metabolic syndrome, neurodegenerative disorders, and CVDs70–72.