The level of IL-22 in BE (75.3 ± 122.2 pg/ml, 75%) was respectively about 17-fold, 16-fold, 1500-fold, and 9.7-fold higher than that in ERM (4.54 ± 7.73 pg/ml, 53%), IOL (4.77 ± 5.60 pg/ml, 46%), sarcoidosis (0.05 ± 0.18 pg/ml, 7%), and ARN (7.75 ± 26.3 pg/ml, 15%). This evidence concerns the gene IL22 and Barrett esophagus.