To explore the effect of EZH2 and TET2 on chromatin structure, we performed FISH in decitabine-treated or untreated U937 cells using probes against 5q−, 7q−, 20q12−, +8, –Y, RB1, 1q21, D13S319 and IgH, which were used as markers of CIN. This evidence concerns the gene TET2 and cervical squamous intraepithelial neoplasia.