Our data showed that Foxm1 loss or inhibition leads to inactivation of the Wnt/β-catenin pathway by destabilizing β-catenin and promoting its degradation in mouse and human leukemia cells, which is distinct from the function of FOXM1 in promoting β-CATENIN nuclear localization instead of β-CATENIN expression in glioblastoma stem cell24. This evidence concerns the gene FOXM1 and leukemia.