The MA9-Foxm1fl/fl recipient mice developed splenomegaly with an infiltration of leukemia cells into spleen and liver, as well as accumulation of myeloid blast cells in peripheral blood (PB), whereas MA9-Foxm1-CKO recipient mice showed normal structure of spleen and liver without detectable myeloid blast cells in PB (Fig. 2g). Here, FOXM1 is linked to Splenomegaly.