To determine whether FOXM1 inhibition suppresses the MV4-11 leukemia cell grown in vivo, we transplanted GFP-labeled MV4-11 cells into NSGS mice (NOD/SCID/IL2rγnull mice expressing human SCF, GMCSF, and IL3)55, to generate cohorts of xenografted mice, followed by treatment with the FOXM1-specific peptide or the natural product thiostrepton, which effectively attenuated FOXM1 expression in human cancer cells in vitro and in vivo in xenograft mice25,51,54,56. The gene discussed is IL3; the disease is cancer.