We show here that the CACNA1I risk variant induces spindle deficits, which corroborated with two recent studies of PTCHD1 and GRIA1, two genes implicated by neuropsychiatric genetics, that abnormal sleep spindle oscillation may underlie neurodevelopmental disorders such as autism and schizophrenia39–41. Here, CACNA1I is linked to neurodevelopmental disorder.