While the previous study on CaV3.3 KO mice reported sigma power deficits during NREM/REM transition19, this report demonstrated sleep spindle occurrences and morphology deficits throughout NREM as well as during NREM/REM transition in mice harboring the RH mutation and lacking CaV3.3 (Fig. 4), thus directly connecting CACNA1I to sleep spindle deficits reported in schizophrenia patients9–11,16–18 during NREM. Here, CACNA1I is linked to schizophrenia.