A dramatic example is provided by CLOVES syndrome (congenital lipomatous overgrowth, vascular malformations, epidermal nevi, scoliosis/skeletal, and spinal syndrome), which is a disorder that results from somatic, mosaic gain-of-function mutations of the PIK3CA gene and that belongs to the spectrum of PIK3CA-related overgrowth syndromes. The gene discussed is PIK3CA; the disease is scoliosis.