Respectively, nuclear Nrf-2 expression showed a tendency to increase following NTG-injection as compared to sham, sham + DMF and sumatriptan groups (Fig. 4(A), see densitometric analysis Fig. 4(A1)); DMF administration, at both doses of 30 and 100 mg/kg, after migraine induction, up-regulated the activities of Nrf-2 (Fig. 4(A), see densitometric analysis Fig. 4(A1)). The gene discussed is NFE2L2; the disease is migraine disorder.