Dimethyl fumarate, DMF, the most pharmacologically effective molecule among the fumaric acid esters (FAEs) and an oral therapeutic agent for the treatment of relapsing-remitting multiple sclerosis (MS) patients [16], was discovered to impact the antioxidative stress cell machinery promoting the transcription of genes downstream to the activation of Nrf-2 [17]. The gene discussed is NFE2L2; the disease is myeloid sarcoma.