As an organellar membrane protein, CLIC3 in late endosome and lysosome promotes migration and invasion of pancreatic ductal adenocarcinoma by recycling integrins [13], and it also dictates invasion and metastasis of breast cancer by controlling recycling of late endosomal membrane-type matrix metalloproteinase-1 (MT1-MMP) [15]. Here, MMP14 is linked to breast cancer.