Meanwhile, a recent study by using NOS2−/− MRL/lpr mice showed a lower level of anti-inflammatory cytokine IL-10 and a higher level of triglycerides, ceramide and sphingosine-1-phosphate (S1P) which aggravate vascular inflammatory processes, suggesting that iNOS may relieve SLE symptoms in some conditions [31]. The gene discussed is NOS2; the disease is systemic lupus erythematosus.