Image analysis also showed that the expression of Beclin1 was significantly lower in the LEP and LEP + HE groups than in the HE group (P < 0.05), and the expression of LC3 was significantly higher in the EEP, LEP, EEP + HE, and LEP + HE groups than in the HE group (P < 0.05). The gene discussed is LEP; the disease is hereditary elliptocytosis.