Recently, ligustilide has attracted widespread attention in the field of Alzheimer’s disease, owing to its capacity to reduce the levels of p-Tau, mutant APP, Aβ1-42 oligomers and monomers, ameliorate oxidative stress induced neuronal apoptosis, provide an effective neuroprotection [19, 20]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.