We previously identified a schizophrenia subject harboring a partial RELN deletion in chr 7 (102919640–102930809, NCBI36/hg18), which includes the region encompassing exons 52–58 encoding reelin repeats 7–8 (Fig. 1a).17, 24 We generated a genetically modified mouse corresponding to this deletion in RELN by genome editing using the CRISPR/Cas9 method; the strain was C57BL/6J, the standard murine line for general behavioral analyses. Here, RELN is linked to schizophrenia.