Collectively, these results indicate that CD4+ αβ T cells are the major driver of AD in Sox13-/- mice and Vβ4+ CD4+ T cell expansion with enhanced IL-22 production is the primary distinguishing feature of αβ T cells in AD, dovetailing with findings in human severe AD (Czarnowicki et al., 2015). This evidence concerns the gene SOX13 and Alzheimer disease.