Incompatible with the pro-inflammatory nature of Vγ2+ Tγδ17 cells,>90% of Sox13-/- mice maintained on a 129/Sv genetic background (>250 mice cumulatively tracked over several years) of both sex develop visible dermatitis in the muzzle, ears, eyes and elsewhere around three to four months of age (Figure 1—figure supplement 1B), displaying many of the hallmarks of human AD (Leung and Guttman-Yassky, 2014; Zheng et al., 2007; Fujita, 2013; Kim, 2015). The gene discussed is SOX13; the disease is dermatitis.