For example, DIRAS3 inhibits gastric cancer and epithelial ovarian cancer cells proliferation and promotes apoptosis by inducing autophagy.26, 27 Up‐regulating the expression of DIRAS3 can enhance the chemosensitivity in both breast cancer and ovarian cancer.28, 29 However, the functional roles of DIRAS3 in glioma were controversial. This evidence concerns the gene DIRAS3 and central nervous system cancer.