The level of autophagy in GBM is declined,21 and TMZ can promote autophagy in malignant glioma cells rather than apoptosis.22, 23 Furthermore, combination of TMZ with bafilomycin A1, an autophagy inhibitor, enhances the chemotherapy effect of TMZ for malignant gliomas.22 However, another study shows that TGF‐β2 induces autophagy to promote invasion of glioma.24 Despite the controversial roles of autophagy in GBM, these investigations suggest autophagy is a promising target for GBM treatment and needs further explorations. This evidence concerns the gene TGFB2 and central nervous system cancer.