The PD‐1/PD‐L1 pathway plays a critical role in the pathophysiology of autoimmune diseases, tumorigenesis, chronic infections, and inflammation.4 A recent study found that activation of the PD‐1/PD‐L1 pathway was associated with hyper‐activation of osteoclasts and impaired T‐cell proliferation in multiple myeloma.5 However, its role in osteoporosis has not yet been studied. Here, CD274 is linked to AL amyloidosis.