Perivascular fibrosis is largely dependent on perivascular inflammation.6 Notably, miR-214 is expressed by immune cells and affects their functions as indicated by studies of tumor immunity17 including possible regulation of profibrotic cytokines, such as TGF-β (transforming growth factor-β) or IL (interleukin)-17.18 This is important as IL-17-mediated vascular stiffening can occur through increasing the deposition of collagen.10 This evidence concerns the gene IL17A and neoplasm.