It has been shown in many studies that high JAB1 expression exists in a variety of malignant tumors, such as head and neck squamous cell carcinoma, cholangiocarcinoma, and colon carcinoma.21, 22, 23, 24 Also, JAB1 expression in tumor tissue is closely associated with the degree of malignancy, which makes JAB1 a promising prognosis prediction tool.22, 25 However, there is currently inadequate research on JAB1 in ESCC. The gene discussed is COPS5; the disease is esophageal squamous cell carcinoma.