Previous research by Wang et al. has shown that JAB1 promotes the progression of malignancies.26 This study revealed JAB1 overexpression in different ESCC cell lines and the role of JAB1 overexpression in ESCC progression as a promoter of cell growth.22, 25 In animal experiments, we found that JAB1 overexpression made tumors of ESCC xenograft models grow faster. Here, COPS5 is linked to esophageal squamous cell carcinoma.