In 2012, Sun et al showed that miR‐320a could directly target β‐catenin to suppress the growth of colon cancer cells.48 Sepramaniam et al in 2010 proved that the precursor miR‐320a functions as an inhibitor of aquaporin 1 and 4 expression but anti‐miR‐320a functions as an activator of aquaporin 1 and 4 expression. This evidence concerns the gene AQP1 and colonic neoplasm.